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pentobarbital will lower the level or effect of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers might enhance the metabolism of ifosfamide to its Lively alkylating m